| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAPN3 |
| Gene ID: | 825 |
| Uniprot ID: | CAN3_HUMAN |
| Immunogen Region: | 1-150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CAPN3 (NP_775111.1). |
| Immunogen Sequence: | MHGNKQHLQKDFFLYNASKA RSKTYINMREVSQRFRLPPS EYVIVPSTYEPHQEGEFILR VFSEKRNLSEEVENTISVDR PVKKKKTKPIIFVSDRANSN KELGVDQESEEGKGKTSPDK QKQSPQPQPGSSDQESEEQQ QFRNIFKQIA |
| Tissue Specificity | Isoform I is skeletal muscle specific. |
| Function | Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53. |
| Protein Name | Calpain-3Calcium-Activated Neutral Proteinase 3Canp 3Calpain L3Calpain P94Muscle-Specific Calcium-Activated Neutral Protease 3New Calpain 1Ncl-1 |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | CytoplasmNucleusNucleolus |
| Alternative Antibody Names | Anti-Calpain-3 antibodyAnti-Calcium-Activated Neutral Proteinase 3 antibodyAnti-Canp 3 antibodyAnti-Calpain L3 antibodyAnti-Calpain P94 antibodyAnti-Muscle-Specific Calcium-Activated Neutral Protease 3 antibodyAnti-New Calpain 1 antibodyAnti-Ncl-1 antibodyAnti-CAPN3 antibodyAnti-CANP3 antibodyAnti-CANPL3 antibodyAnti-NCL1 antibody |
Information sourced from Uniprot.org
