| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CAMKK2 (1-100) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CAMKK2 |
| Gene ID: |
10645 |
| Uniprot ID: |
KKCC2_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CAMKK2 (NP_006540.3). |
| Immunogen Sequence: |
MSSCVSSQPSSNRAAPQDEL GGRGSSSSESQKPCEALRGL SSLSIHLGMESFIVVTECEP GCAVDLGLARDRPLEADGQE VPLDTSGSQARPHLSGRKLS |
| Tissue Specificity | Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. |
| Post Translational Modifications | Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. |
| Function | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 2Cam-Kk 2Cam-Kinase Kinase 2Camkk 2Calcium/Calmodulin-Dependent Protein Kinase Kinase BetaCam-Kk BetaCam-Kinase Kinase BetaCamkk Beta |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-442729Reactome: R-HSA-9619229Reactome: R-HSA-9619483 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionNeuron ProjectionPredominantly Nuclear In Unstimulated CellsRelocalizes Into Cytoplasm And Neurites After Forskolin Induction |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 antibodyAnti-Cam-Kk 2 antibodyAnti-Cam-Kinase Kinase 2 antibodyAnti-Camkk 2 antibodyAnti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta antibodyAnti-Cam-Kk Beta antibodyAnti-Cam-Kinase Kinase Beta antibodyAnti-Camkk Beta antibodyAnti-CAMKK2 antibodyAnti-CAMKKB antibodyAnti-KIAA0787 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
