Anti-CaMKII Beta/Gamma antibody (509-558 aa) (STJ91990)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CaMK2 beta/gamma at the amino acid range 509-558
General Information
| Short Description | Rabbit polyclonal anti-Calcium/calmodulin-dependent protein kinase type II subunit gamma and Calcium/calmodulin-dependent protein kinase type II subunit beta (509-558 aa) for use in WB, IF and ELISA in Human, Mouse and Rat samples. Datasheet included |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAMK2BCAMK2G |
| Gene ID | 816818 |
| Uniprot ID | KCC2B_HUMANKCC2G_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CaMK2 beta/gamma at the amino acid range 509-558 |
| Immunogen Region | 509-558 aa |
| Specificity | CaMKII Beta/Gamma Polyclonal Antibody detects endogenous levels of CaMKII Beta/Gamma protein. |
Additional Info
| Post Translational Modifications | Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit GammaCam Kinase Ii Subunit GammaCamk-Ii Subunit Gamma |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-3371571Reactome: R-HSA-399719Reactome: R-HSA-438066Reactome: R-HSA-442729Reactome: R-HSA-442982Reactome: R-HSA-5576892Reactome: R-HSA-5578775Reactome: R-HSA-5673000Reactome: R-HSA-5673001Reactome: R-HSA-6802946Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-877300Reactome: R-HSA-9022692Reactome: R-HSA-936837Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Sarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Gamma antibodyAnti-Cam Kinase Ii Subunit Gamma antibodyAnti-Camk-Ii Subunit Gamma antibodyAnti-CAMK2G antibodyAnti-CAMK antibodyAnti-CAMK-II antibodyAnti-CAMKG antibody |
Information sourced from Uniprot.org