| Host: | Rabbit |
| Applications: | IHC/IF/WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Calcium/calmodulin-dependent protein kinase type II subunit alpha and Calcium/calmodulin-dependent protein kinase type II subunit beta and Calcium/calmodulin-dependent protein kinase type II subunit delta (271-320 aa) |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAMK2B CAMK2D 816 817 815 KCC2B_HUMAN KCC2D_HUMAN KCC2A_HUMAN |
| Immunogen Region: | 271-320 aa |
| Specificity: | CaMKII Alpha/Beta/Delta Polyclonal Antibody detects endogenous levels of CaMKII Alpha/Beta/Delta protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CaMK2 alpha/beta/delta at the amino acid range 271-320 |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha Cam Kinase Ii Subunit Alpha Camk-Ii Subunit Alpha |
| Database Links | Reactome: R-HSA-111932 Reactome: R-HSA-3371571 Reactome: R-HSA-399719 Reactome: R-HSA-4086398 Reactome: R-HSA-438066 Reactome: R-HSA-442982 Reactome: R-HSA-5576892 Reactome: R-HSA-5578775 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-6802946 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-877300 Reactome: R-HSA-9022692 Reactome: R-HSA-936837 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell Junction Synapse Postsynaptic Density Cell Projection Dendritic Spine Dendrite Postsynaptic Lipid Rafts |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha antibody Anti-Cam Kinase Ii Subunit Alpha antibody Anti-Camk-Ii Subunit Alpha antibody Anti-CAMK2A antibody Anti-CAMKA antibody Anti-KIAA0968 antibody |
Information sourced from Uniprot.org