Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Gamma (300-410) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:100 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CAMK2G |
Gene ID: | 818 |
Uniprot ID: | KCC2G_HUMAN |
Immunogen Region: | 300-410 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-410 of human CAMK2G (NP_751909.1). |
Immunogen Sequence: | LKGAILTTMLVSRNFSVGRQ SSAPASPAASAAGLAGQAAK SLLNKKSDGGVKKRKSSSSV HLMEPQTTVVHNATDGIKGS TESCNTTTEDEDLKVRKQEI IKITEQLIEAI |
Tissue Specificity | Expressed in skeletal muscle. |
Post Translational Modifications | Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. |
Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. |
Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Gamma Cam Kinase Ii Subunit Gamma Camk-Ii Subunit Gamma |
Database Links | Reactome: R-HSA-111932 Reactome: R-HSA-3371571 Reactome: R-HSA-399719 Reactome: R-HSA-438066 Reactome: R-HSA-442729 Reactome: R-HSA-442982 Reactome: R-HSA-5576892 Reactome: R-HSA-5578775 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-6802946 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-877300 Reactome: R-HSA-9022692 Reactome: R-HSA-936837 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 |
Cellular Localisation | Sarcoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side |
Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Gamma antibody Anti-Cam Kinase Ii Subunit Gamma antibody Anti-Camk-Ii Subunit Gamma antibody Anti-CAMK2G antibody Anti-CAMK antibody Anti-CAMK-II antibody Anti-CAMKG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance