| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:5000-1:12000 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAMK2B |
| Gene ID: | 816 |
| Uniprot ID: | KCC2B_HUMAN |
| Immunogen Region: | 200-300 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CaMK2 delta/CAMK2 gamma (Q13554). |
| Immunogen Sequence: | CGVILYILLVGYPPFWDEDQ HKLYQQIKAGAYDFPSPEWD TVTPEAKNLINQMLTINPAK RITAHEALKHPWVCQRSTVA SMMHRQETVECLKKFNARRK L |
| Tissue Specificity | Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. |
| Post Translational Modifications | Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Beta Cam Kinase Ii Subunit Beta Camk-Ii Subunit Beta |
| Database Links | Reactome: R-HSA-111932 Reactome: R-HSA-3371571 Reactome: R-HSA-399719 Reactome: R-HSA-438066 Reactome: R-HSA-442729 Reactome: R-HSA-442982 Reactome: R-HSA-5576892 Reactome: R-HSA-5578775 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-6802946 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-877300 Reactome: R-HSA-9022692 Reactome: R-HSA-936837 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 |
| Cellular Localisation | Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Sarcoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side Synapse In Slow-Twitch Muscle Evenly Distributed Between Longitudinal Sr And Junctional Sr |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Beta antibody Anti-Cam Kinase Ii Subunit Beta antibody Anti-Camk-Ii Subunit Beta antibody Anti-CAMK2B antibody Anti-CAM2 antibody Anti-CAMK2 antibody Anti-CAMKB antibody |
Information sourced from Uniprot.org