| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CALU |
| Gene ID: | 813 |
| Uniprot ID: | CALU_HUMAN |
| Immunogen Region: | 20-315 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_001210.1). |
| Immunogen Sequence: | KPTEKKDRVHHEPQLSDKVH NDAQSFDYDHDAFLGAEEAK TFDQLTPEESKERLGKIVSK IDGDKDGFVTVDELKDWIKF AQKRWIYEDVERQWKGHDLN EDGLVSWEEYKNATYGYVLD DPDPDDGFNYKQMMVRDERR FKMADKDGDLIATKEEFTAF LHPEEYDYMKDIVVQETMED IDKNADGFIDLEEYIGDMYS HDGNTDEPEWVKTEREQFVE FRDKNRDGKMDKEETKDWI |
| Tissue Specificity | Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver. |
| Function | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity. |
| Protein Name | CalumeninCrocalbinIef Ssp 9302 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum MembraneGolgi ApparatusSecretedMelanosomeSarcoplasmic Reticulum LumenIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Calumenin antibodyAnti-Crocalbin antibodyAnti-Ief Ssp 9302 antibodyAnti-CALU antibody |
Information sourced from Uniprot.org
