| Post Translational Modifications | Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity. N-glycosylated. |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2.this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. |
| Protein Name | Calsequestrin-2Calsequestrin - Cardiac Muscle Isoform |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum LumenThis Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Cardiac And Slow Skeletal Muscle Cells |
| Alternative Antibody Names | Anti-Calsequestrin-2 antibodyAnti-Calsequestrin - Cardiac Muscle Isoform antibodyAnti-CASQ2 antibody |
Information sourced from Uniprot.org
