Anti-Calpain 2 antibody [R08-7I8] (STJA0036512)

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STJA0036512
£133.50 - £281.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Calpain 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R08-7I8
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Chromatography
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: CAPN2
Gene ID: 824
Uniprot ID: CAN2_HUMAN
Immunogen: A synthesized peptide derived from human Calpain 2
Tissue Specificity Ubiquitous.
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs.
Protein Name Calpain-2 Catalytic Subunit
Calcium-Activated Neutral Proteinase 2
Canp 2
Calpain M-Type
Calpain Large Polypeptide L2
Calpain-2 Large Subunit
Millimolar-Calpain
M-Calpain
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-8862803
Reactome: R-HSA-9856530
Reactome: R-HSA-9860927
Cellular Localisation Cytoplasm
Cell Membrane
Translocates To The Plasma Membrane Upon Ca(2+) Binding
Alternative Antibody Names Anti-Calpain-2 Catalytic Subunit antibody
Anti-Calcium-Activated Neutral Proteinase 2 antibody
Anti-Canp 2 antibody
Anti-Calpain M-Type antibody
Anti-Calpain Large Polypeptide L2 antibody
Anti-Calpain-2 Large Subunit antibody
Anti-Millimolar-Calpain antibody
Anti-M-Calpain antibody
Anti-CAPN2 antibody
Anti-CANPL2 antibody

Information sourced from Uniprot.org

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