| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CACNB2 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | CACNB2 |
| Gene ID: | 783 |
| Uniprot ID: | CACB2_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | Specific for CACNB2. |
| Immunogen: | A synthetic peptide from the c-terminal region of human CACNB2 (CAB2, MYSB) conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Regulated through phosphorylation at Thr-554 by CaMK2D. |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2Cab2Calcium Channel Voltage-Dependent Subunit Beta 2Lambert-Eaton Myasthenic Syndrome Antigen BMysb |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-400042Reactome: R-HSA-419037Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-9662360 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 antibodyAnti-Cab2 antibodyAnti-Calcium Channel Voltage-Dependent Subunit Beta 2 antibodyAnti-Lambert-Eaton Myasthenic Syndrome Antigen B antibodyAnti-Mysb antibodyAnti-CACNB2 antibodyAnti-CACNLB2 antibodyAnti-MYSB antibody |
Information sourced from Uniprot.org
