| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-CACNB2 (565-579) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 65kDa band observed in lysates of cell lines NIH3T3 and Jurkat (calculated MW of 68.1kDa according to NP_000715.2). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CACNB2 |
| Gene ID: | 783 |
| Uniprot ID: | CACB2_HUMAN |
| Immunogen Region: | 565-579 |
| Accession Number: | NP_000715.2; NP_963890.2; NP_963884.2; NP_963891.1; NP_963887.2; NP_963865.2; NP_963864.1; NP_963866.2; NP_001161417.1 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_000715.2; NP_963890.2; NP_963884.2; NP_963891.1; NP_963887.2; NP_963865.2; NP_963864.1; NP_963866.2; NP_001161417.1). |
| Immunogen Sequence: | ECNKQRSRHKSKDRY |
| Post Translational Modifications | Regulated through phosphorylation at Thr-554 by CaMK2D. |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2Cab2Calcium Channel Voltage-Dependent Subunit Beta 2Lambert-Eaton Myasthenic Syndrome Antigen BMysb |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-400042Reactome: R-HSA-419037Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-9662360 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 antibodyAnti-Cab2 antibodyAnti-Calcium Channel Voltage-Dependent Subunit Beta 2 antibodyAnti-Lambert-Eaton Myasthenic Syndrome Antigen B antibodyAnti-Mysb antibodyAnti-CACNB2 antibodyAnti-CACNLB2 antibodyAnti-MYSB antibody |
Information sourced from Uniprot.org
