| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNB2 (500-600) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.6 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Cacnb2 |
| Gene ID: |
116600 |
| Uniprot ID: |
CACB2_RAT |
| Immunogen Region: |
500-600 |
| Immunogen: |
Synthetic peptide taken within amino acid region 500-600 on rat voltage-dependent L-type calcium channel subunit beta-2 protein |
| Tissue Specificity | Highly expressed in heart and brain, and at lower levels in lung. |
| Post Translational Modifications | Regulated through phosphorylation at Thr-549 by CaMK2D. |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Beta-2Cab2Calcium Channel Voltage-Dependent Subunit Beta 2 |
| Database Links | Reactome: R-RNO-112308Reactome: -RNO-422356Reactome: -RNO-5576892Reactome: -RNO-5576893 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 antibodyAnti-Cab2 antibodyAnti-Calcium Channel Voltage-Dependent Subunit Beta 2 antibodyAnti-Cacnb2 antibodyAnti-Cacnlb2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
