| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Voltage-dependent L-type calcium channel subunit alpha-1S (330-410 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA1S |
| Gene ID: |
779 |
| Uniprot ID: |
CAC1S_HUMAN |
| Immunogen Region: |
330-410 aa |
| Specificity: |
CAC1S Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 330-410 |
| Post Translational Modifications | The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690. Phosphorylated. Phosphorylation by PKA activates the calcium channel. Both the minor and major forms are phosphorylated in vitro by PKA. Phosphorylation at Ser-1575 is involved in beta-adrenergic-mediated regulation of the channel. |
| Function | Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1sCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal MuscleVoltage-Gated Calcium Channel Subunit Alpha Cav1.1 |
| Database Links | Reactome: R-HSA-419037 |
| Cellular Localisation | Cell MembraneSarcolemmaT-TubuleMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.1 antibodyAnti-CACNA1S antibodyAnti-CACH1 antibodyAnti-CACN1 antibodyAnti-CACNL1A3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
