| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNA1C (1700-1800 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Cacna1c |
| Gene ID: |
12288 |
| Uniprot ID: |
CAC1C_MOUSE |
| Immunogen Region: |
1700-1800 aa |
| Specificity: |
Specific for CACNA1C. |
| Immunogen: |
A synthetic peptide from aa region 1700-1800 of mouse CACNA1C (Cav1.2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylation by PKA at Ser-1897 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA. |
| Function | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1cCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac MuscleMelc-CcMouse Brain Class CMbcVoltage-Gated Calcium Channel Subunit Alpha Cav1.2 |
| Database Links | Reactome: R-MMU-422356Reactome: -MMU-5576892Reactome: -MMU-5576893 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaPerikaryonPostsynaptic Density MembraneCell ProjectionDendriteT-TubuleColocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional MembraneWhere The Sarcolemma And The Sarcoplasmic Reticulum Are In Close ContactThe Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell MembraneLocalized In T-TubulesAs Shown In Serca2-Knockout Cardiomyocytes |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle antibodyAnti-Melc-Cc antibodyAnti-Mouse Brain Class C antibodyAnti-Mbc antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 antibodyAnti-Cacna1c antibodyAnti-Cach2 antibodyAnti-Cacn2 antibodyAnti-Cacnl1a1 antibodyAnti-Cchl1a1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
