| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C8orf4 (1-106) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TCIM |
| Gene ID: |
56892 |
| Uniprot ID: |
TCIM_HUMAN |
| Immunogen Region: |
1-106 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1). |
| Immunogen Sequence: |
MKAKRSHQAIIMSTSLRVSP SIHGYHFDTASRKKAVGNIF ENTDQESLERLFRNSGDKKA EERAKIIFAIDQDVEEKTRA LMALKKRTKDKLFQFLKLRK YSIKVH |
| Tissue Specificity | Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma. Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level). |
| Function | Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown. In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling. |
| Protein Name | Transcriptional And Immune Response RegulatorThyroid Cancer Protein 1Tc-1 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleus SpeckleLocalizes In Nucleus Speckles In Presence Of Cby1Translocates To The Nucleus Upon Cellular Stress Such As H(2)O(2) |
| Alternative Antibody Names | Anti-Transcriptional And Immune Response Regulator antibodyAnti-Thyroid Cancer Protein 1 antibodyAnti-Tc-1 antibodyAnti-TCIM antibodyAnti-C8orf4 antibodyAnti-TC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
