| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
C8A |
| Gene ID: |
731 |
| Uniprot ID: |
CO8A_HUMAN |
| Immunogen Region: |
310-460 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 310-460 of human C8A (NP_000553.1). |
| Immunogen Sequence: |
LDEGMLQSLMELPDQYNYGM YAKFINDYGTHYITSGSMGG IYEYILVIDKAKMESLGITS RDITTCFGGSLGIQYEDKIN VGGGLSGDHCKKFGGGKTER ARKAMAVEDIISRVRGGSSG WSGGLAQNRSTITYRSWGRS LKYNPVVIDFE |
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. |
| Protein Name | Complement Component C8 Alpha ChainComplement Component 8 Subunit Alpha |
| Database Links | Reactome: R-HSA-166665Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedCell MembraneMulti-Pass Membrane ProteinSecreted As Soluble ProteinInserts Into The Cell Membrane Of Target Cells |
| Alternative Antibody Names | Anti-Complement Component C8 Alpha Chain antibodyAnti-Complement Component 8 Subunit Alpha antibodyAnti-C8A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
