Anti-C6/Complement C6 antibody [Fs0372] (STJA0032115)

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STJA0032115-100
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Host: Human
Applications: ELISA/Neut
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Human monoclonal anti-C6/Complement C6 for use in ELISA and Neut in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : Fs0372
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Endotoxin: Please contact us for this information.
Gene Symbol: C6
Gene ID: 729
Uniprot ID: CO6_HUMAN
Function Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending.
Protein Name Complement Component C6
Database Links Reactome: R-HSA-166665
Reactome: R-HSA-977606
Cellular Localisation Secreted
Target Cell Membrane
Multi-Pass Membrane Protein
Secreted As Soluble Protein
Inserts Into The Cell Membrane Of Target Cells
Alternative Antibody Names Anti-Complement Component C6 antibody
Anti-C6 antibody

Information sourced from Uniprot.org

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