Anti-C1S antibody (541-590 aa) (STJ91932)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human C1S at the amino acid range 541-590
General Information
| Short Description | Rabbit polyclonal anti-Complement C1s subcomponent (541-590 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C1S |
| Gene ID | 716 |
| Uniprot ID | C1S_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human C1S at the amino acid range 541-590 |
| Immunogen Region | 541-590 aa |
| Specificity | C1s Polyclonal Antibody detects endogenous levels of C1s protein. |
Additional Info
| Function | Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway. Complement C1s subcomponent light chain: Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also able to cleave C1 inhibitor (SERPING1) in vitro.additional evidence is however required to confirm this result in vivo. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1. |
| Protein Name | Complement C1s SubcomponentC1 EsteraseComplement Component 1 Subcomponent S Cleaved Into - Complement C1s Subcomponent Heavy ChainComplement C1s Subcomponent Chain A - Complement C1s Subcomponent Light ChainComplement C1s Subcomponent Chain B |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedCell SurfaceRecruited To The Surface Of Pathogens By The C1q Subcomplex |
| Alternative Antibody Names | Anti-Complement C1s Subcomponent antibodyAnti-C1 Esterase antibodyAnti-Complement Component 1 Subcomponent S Cleaved Into - Complement C1s Subcomponent Heavy Chain antibodyAnti-Complement C1s Subcomponent Chain A - Complement C1s Subcomponent Light Chain antibodyAnti-Complement C1s Subcomponent Chain B antibodyAnti-C1S antibody |
Information sourced from Uniprot.org