| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C1QBP (52-459) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
C1QBP |
| Gene ID: |
708 |
| Uniprot ID: |
C1QBP_HUMAN |
| Immunogen Region: |
52-459 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 52-459 of human GC1q R/GC1q R/C1QBP (NP_001207.2). |
| Immunogen Sequence: |
GSSGEDDPLGEEDLPSEEDS PREEDPPGEEDLPGEEDLPG EEDLPEVKPKSEEEGSLKLE DLPTVEAPGDPQEPQNNAHR DKEGDDQSHWRYGGDPPWPR |
| Tissue Specificity | Expressed on cell surface of peripheral blood cells (at protein level).Surface expression is reported for macrophages and monocyte-derived dendritic cells. |
| Function | Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q.specifically binds to the globular 'heads' of C1q thus inhibiting C1.may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes.the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process.the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response.ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. (Microbial infection) Involved in replication of Rubella virus. |
| Protein Name | Complement Component 1 Q Subcomponent-Binding Protein - MitochondrialAsf/Sf2-Associated Protein P32Glycoprotein Gc1qbpC1qbpHyaluronan-Binding Protein 1Mitochondrial Matrix Protein P32Gc1q-R ProteinP33Sf2ap32 |
| Database Links | Reactome: R-HSA-111471Reactome: R-HSA-140837Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9645722 |
| Cellular Localisation | Mitochondrion MatrixNucleusNucleolusCell MembranePeripheral Membrane ProteinExtracellular SideSecretedCytoplasmSeems To Be Predominantly Localized To MitochondriaSecreted By Activated LymphocytesLocalizes To The Nucleolus When Coexpressed With PolgarfInteraction With Polgarf Is Likely To Result In Prevention Of C1qbp Maturation And Redirection From Mitochondria To Nucleoli |
| Alternative Antibody Names | Anti-Complement Component 1 Q Subcomponent-Binding Protein - Mitochondrial antibodyAnti-Asf/Sf2-Associated Protein P32 antibodyAnti-Glycoprotein Gc1qbp antibodyAnti-C1qbp antibodyAnti-Hyaluronan-Binding Protein 1 antibodyAnti-Mitochondrial Matrix Protein P32 antibodyAnti-Gc1q-R Protein antibodyAnti-P33 antibodyAnti-Sf2ap32 antibodyAnti-C1QBP antibodyAnti-GC1QBP antibodyAnti-HABP1 antibodyAnti-SF2P32 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
