Anti-c-FOS antibody (283-295) (STJ72884)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-c-FOS (283-295) is suitable for use in ELISA, Immunofluorescence and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IF/IHC |
| Host | Goat |
| Reactivity | Human/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.IHC: Paraffin embedded Human Tonsil. Recommended concentration: 8ยตg/ml.IF: Strong expression of the protein seen in the nucleus of HeLa cells, and in the ER and cytoplasm of MCF7 cel |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | FOS |
| Gene ID | 2353 |
| Uniprot ID | FOS_HUMAN |
| Accession Number | NP_005243.1 |
| Immunogen Region | 283-295 |
| Immunogen Sequence | SETARSVPDMDLS |
Additional Info
| Function | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Protein Name | Protein C-FosCellular Oncogene FosFos Proto-Oncogene - Ap-1 Transcription Factor SubunitG0/G1 Switch Regulatory Protein 7Proto-Oncogene C-FosTranscription Factor Ap-1 Subunit C-Fos |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2871796Reactome: R-HSA-450341Reactome: R-HSA-6785807Reactome: R-HSA-6796648Reactome: R-HSA-9018519Reactome: R-HSA-9031628Reactome: R-HSA-9634638Reactome: R-HSA-9768919 |
| Cellular Localisation | NucleusEndoplasmic ReticulumCytoplasmCytosolIn Quiescent CellsPresent In Very Small Amounts In The CytosolFollowing Induction Of Cell GrowthFirst Localizes To The Endoplasmic Reticulum And Only Later To The NucleusLocalization At The Endoplasmic Reticulum Requires Dephosphorylation At Tyr-10 And Tyr-30 |
| Alternative Antibody Names | Anti-Protein C-Fos antibodyAnti-Cellular Oncogene Fos antibodyAnti-Fos Proto-Oncogene - Ap-1 Transcription Factor Subunit antibodyAnti-G0/G1 Switch Regulatory Protein 7 antibodyAnti-Proto-Oncogene C-Fos antibodyAnti-Transcription Factor Ap-1 Subunit C-Fos antibodyAnti-FOS antibodyAnti-G0S7 antibody |
Information sourced from Uniprot.org