| Post Translational Modifications | May be ubiquitinated and targeted to degradation in response to pro-inflammatory cytokine signaling. |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro. |
| Protein Name | 18s RrnaGuanine-N(7-MethyltransferaseBud Site Selection Protein 23 HomologMetastasis-Related Methyltransferase 1Williams-Beuren Syndrome Chromosomal Region 22 ProteinRrna Methyltransferase And Ribosome Maturation Factor |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPerinuclear RegionLocalized Diffusely Throughout The Nucleus And The CytoplasmLocalizes To A Polarized Perinuclear StructureOverlapping Partially With The Golgi And LysosomesLocalization Is Not Affected By Glucocorticoid Treatment |
| Alternative Antibody Names | Anti-18s Rrna antibodyAnti-Guanine-N(7-Methyltransferase antibodyAnti-Bud Site Selection Protein 23 Homolog antibodyAnti-Metastasis-Related Methyltransferase 1 antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 22 Protein antibodyAnti-Rrna Methyltransferase And Ribosome Maturation Factor antibodyAnti-BUD23 antibodyAnti-MERM1 antibodyAnti-WBSCR22 antibodyAnti-HUSSY-03 antibodyAnti-PP3381 antibody |
Information sourced from Uniprot.org
