| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | BTBD10 |
| Gene ID: | 84280 |
| Uniprot ID: | BTBDA_HUMAN |
| Immunogen Region: | 1-180 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human BTBD10 (NP_115696.2). |
| Immunogen Sequence: | MAGRPHPYDGNSSDPENWDR KLHSRPRKLYKHSSTSSRIA KGGVDHTKMSLHGASGGHER SRDRRRSSDRSRDSSHERTE SQLTPCIRNVTSPTRQHHVE REKDHSSSRPSSPRPQKASP NGSISSAGNSSRNSSQSSSD GSCKTAGEMVFVYENAKEGA RNIRTSERVTLIVDNTRFVV |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma. |
| Function | Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. |
| Protein Name | Btb/Poz Domain-Containing Protein 10Glucose Metabolism-Related Protein 1 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Kctd20 In Filamentous Structures |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein 10 antibodyAnti-Glucose Metabolism-Related Protein 1 antibodyAnti-BTBD10 antibodyAnti-GMRP1 antibody |
Information sourced from Uniprot.org