| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein Bassoon (830-950) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BSN |
| Gene ID: |
8927 |
| Uniprot ID: |
BSN_HUMAN |
| Immunogen Region: |
830-950 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 830-950 of human BSN (NP_003449.2). |
| Immunogen Sequence: |
PPARAAELTDEDFMRRQILE MSAEEDNLEEDDTATSGRGL AKHGTQKGGPRPRPEPSQEP AALPKRRLPHNATTGYEELL PEGGSAEATDGSGTLQGGLR RFKTIELNSTGSYGHELDLG Q |
| Tissue Specificity | Exclusively expressed in brain. |
| Post Translational Modifications | Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization. |
| Function | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts. At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis. Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5. Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import. |
| Protein Name | Protein BassoonZinc Finger Protein 231 |
| Database Links | Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmPresynaptic Active ZoneCytoskeletonCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembranePeripheral Membrane ProteinIn RetinaIs Localized In The Outer Plexiform Layer At Ribbon Synapses Formed By Rods And Cones But Was Absent From Basal Synaptic Contacts Formed By ConesIn The Retinal Inner Plexiform Layer Localized To Conventional Inhibitory Gabaergic SynapsesMade By Amacrine CellsBut Absent From The Bipolar Cell Ribbon Synapses |
| Alternative Antibody Names | Anti-Protein Bassoon antibodyAnti-Zinc Finger Protein 231 antibodyAnti-BSN antibodyAnti-KIAA0434 antibodyAnti-ZNF231 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
