Anti-BRMS1 antibody (1-100) [S9MR] (STJ11102709)

Name: Anti-BRMS1 antibody (1-100) [S9MR] (STJ11102709)
SKU: STJ11102709
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11102709

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Short Description	Rabbit monoclonal BRMS1 (1-100) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S9MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	BRMS1
Gene ID	25855
Uniprot ID	BRMS1_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MPVQPPSKDTEEMEAEGDSA AEMNGEEEESEEERSGSQTE SEEESSEMDDEDYERRRSEC VSEMLDLEKQFSELKEKLFR ERLSQLRLRLEEVGAERAPE
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRMS1 (Q9HCU9).

Tissue Specificity	Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Post Translational Modifications	Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
Function	Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Protein Name	Breast Cancer Metastasis-Suppressor 1
Database Links	Reactome: R-HSA-3214815 Reactome: R-HSA-9679191
Cellular Localisation	Nucleus Cytoplasm Predominantly Nuclear
Alternative Antibody Names	Anti-Breast Cancer Metastasis-Suppressor 1 antibody Anti-BRMS1 antibody

Information sourced from Uniprot.org