| Tissue Specificity | Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. |
| Function | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. |
| Protein Name | Bromodomain-Containing Protein 8Skeletal Muscle Abundant ProteinSkeletal Muscle Abundant Protein 2Thyroid Hormone Receptor Coactivating Protein Of 120 KdaTrcp120P120 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Bromodomain-Containing Protein 8 antibodyAnti-Skeletal Muscle Abundant Protein antibodyAnti-Skeletal Muscle Abundant Protein 2 antibodyAnti-Thyroid Hormone Receptor Coactivating Protein Of 120 Kda antibodyAnti-Trcp120 antibodyAnti-P120 antibodyAnti-BRD8 antibodyAnti-SMAP antibodyAnti-SMAP2 antibody |
Information sourced from Uniprot.org
