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Anti-BPTF antibody [2F10] (STJ97882)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human BPTF expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Nucleosome-remodeling factor subunit BPTF for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2F10 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BPTF |
| Gene ID | 2186 |
| Uniprot ID | BPTF_HUMAN |
| Immunogen | Purified recombinant fragment of human BPTF expressed in E. Coli. |
| Specificity | BPTF Monoclonal Antibody detects endogenous levels of BPTF protein. |
Additional Info
| Post Translational Modifications | Phosphorylation enhances DNA-binding. Highly susceptible to proteolysis. |
| Function | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors. |
| Protein Name | Nucleosome-Remodeling Factor Subunit BptfBromodomain And Phd Finger-Containing Transcription FactorFetal Alz-50 Clone 1 ProteinFetal Alzheimer Antigen |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLocalizes To Sites Of Dna DamageIn Brains Of Alzheimer Disease PatientsPresent In A Subset Of Amyloid-Containing Plaques |
| Alternative Antibody Names | Anti-Nucleosome-Remodeling Factor Subunit Bptf antibodyAnti-Bromodomain And Phd Finger-Containing Transcription Factor antibodyAnti-Fetal Alz-50 Clone 1 Protein antibodyAnti-Fetal Alzheimer Antigen antibodyAnti-BPTF antibodyAnti-FAC1 antibodyAnti-FALZ antibody |
Information sourced from Uniprot.org