Anti-BNIP3 antibody [R09-1G8] (STJA0033937)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human BNIP3
General Information
| Short Description | Rabbit monoclonal anti-BNIP3 for use in WB, ICC and IF in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-1G8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | BNIP3 |
| Gene ID | 664 |
| Uniprot ID | BNIP3_HUMAN |
| Immunogen | A synthetic peptide of human BNIP3 |
Additional Info
| Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 |
| Database Links | |
| Cellular Localisation | MitochondrionMitochondrion Outer MembraneSingle-Pass Membrane ProteinCoexpression With The Eib 19-Kda Protein Results In A Shift In Nip3 Localization Pattern To The Nuclear EnvelopeColocalizes With Acaa2 In The MitochondriaColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 antibodyAnti-BNIP3 antibodyAnti-NIP3 antibody |
Information sourced from Uniprot.org