| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:100-1:500 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BMPR1B |
| Gene ID: | 658 |
| Uniprot ID: | BMR1B_HUMAN |
| Immunogen Region: | 1-126 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human BMPR1B (NP_001194.1). |
| Immunogen Sequence: | MLLRSAGKLNVGTKKEDGES TAPTPRPKVLRCKCHHHCPE DSVNNICSTDGYCFTMIEED DSGLPVVTSGCLGLEGSDFQ CRDTPIPHQRRSIECCTERN ECNKDLHPTLPPLKNRDFVD GPIHHR |
| Post Translational Modifications | Autophosphorylated. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-1b Bmp Type-1b Receptor Bmpr-1b Cd Antigen Cdw293 |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein Receptor Type-1b antibody Anti-Bmp Type-1b Receptor antibody Anti-Bmpr-1b antibody Anti-Cd Antigen Cdw293 antibody Anti-BMPR1B antibody |
Information sourced from Uniprot.org