Anti-BMP6 antibody [SAA0425] {PerCP} (STJA0030260)

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STJA0030260
€331.88 - €495.63
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Host: Mouse
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Bone Morphogenetic Protein 6 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0425
Conjugation: PerCP
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: BMP6
Gene ID: 654
Uniprot ID: BMP6_HUMAN
Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.
Protein Name Bone Morphogenetic Protein 6
Bmp-6
Vg-1-Related Protein
Vg-1-R
Vgr-1
Cellular Localisation Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 6 antibody
Anti-Bmp-6 antibody
Anti-Vg-1-Related Protein antibody
Anti-Vg-1-R antibody
Anti-Vgr-1 antibody
Anti-BMP6 antibody
Anti-VGR antibody

Information sourced from Uniprot.org