Anti-BMP4 antibody [SAA0424] {PerCP} (STJA0030117)

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STJA0030117
€331.88 - €495.63
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Host: Mouse
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Bone Morphogenetic Protein 4 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0424
Conjugation: PerCP
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: BMP4
Gene ID: 652
Uniprot ID: BMP4_HUMAN
Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response.
Protein Name Bone Morphogenetic Protein 4
Bmp-4
Bone Morphogenetic Protein 2b
Bmp-2b
Database Links Reactome: R-HSA-2129379
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Reactome: R-HSA-9754189
Reactome: R-HSA-9758920
Reactome: R-HSA-9761174
Reactome: R-HSA-9793380
Reactome: R-HSA-9827857
Reactome: R-HSA-9830364
Reactome: R-HSA-9830674
Reactome: R-HSA-9834899
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Bone Morphogenetic Protein 4 antibody
Anti-Bmp-4 antibody
Anti-Bone Morphogenetic Protein 2b antibody
Anti-Bmp-2b antibody
Anti-BMP4 antibody
Anti-BMP2B antibody
Anti-DVR4 antibody

Information sourced from Uniprot.org