Anti-BMP3 antibody (Internal) (STJ71562)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-BMP3 (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Preliminary experiments gave an approx 29kDa band in Human Bone Marrow lysates after 1ยตg/ml antibody staining. Please note that currently we cannot find an explanation in the literature |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP3 |
| Gene ID | 651 |
| Uniprot ID | BMP3_HUMAN |
| Accession Number | NP_001192.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | GHRNFPTGTV PKWDSH |
Additional Info
| Function | Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. |
| Protein Name | Bone Morphogenetic Protein 3Bmp-3Bone Morphogenetic Protein 3aBmp-3aOsteogenin |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 3 antibodyAnti-Bmp-3 antibodyAnti-Bone Morphogenetic Protein 3a antibodyAnti-Bmp-3a antibodyAnti-Osteogenin antibodyAnti-BMP3 antibodyAnti-BMP3A antibody |
Information sourced from Uniprot.org