Anti-BMP3 antibody (243-472) (STJ28957)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BMP3 (243-472) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP3 |
| Gene ID | 651 |
| Uniprot ID | BMP3_HUMAN |
| Immunogen Region | 243-472 |
| Immunogen Sequence | YANDAAISEPESVVSSLQGH RNFPTGTVPKWDSHIRAALS IERRKKRSTGVLLPLQNNEL PGAEYQYKKDEVWEERKPYK TLQAQAPEKSKNKKKQRKGP HRKSQTLQFDEQTLKKARRK QWIEPRNCARRYLKVDFADI GWSEWIISPKSFDAYYCSGA CQFPMPKSLKPSNHATIQSI VRAVGVVPGIPEPCCVPEKM SSLSILFFDENKNVVLKVYP NMTVESCACR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 243-472 of human BMP3 (NP_001192.2). |
Additional Info
| Tissue Specificity | Expressed in adult and fetal cartilage. |
| Function | Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. |
| Protein Name | Bone Morphogenetic Protein 3Bmp-3Bone Morphogenetic Protein 3aBmp-3aOsteogenin |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 3 antibodyAnti-Bmp-3 antibodyAnti-Bone Morphogenetic Protein 3a antibodyAnti-Bmp-3a antibodyAnti-Osteogenin antibodyAnti-BMP3 antibodyAnti-BMP3A antibody |
Information sourced from Uniprot.org