| Host: |
Rabbit |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal anti-BMI1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : |
Monoclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Purification: |
Affinity Purified |
| Dilution Range: |
IHC 1:100-1:200 |
| Storage Instruction: |
Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Post Translational Modifications | Monoubiquitinated. May be polyubiquitinated.which does not lead to proteasomal degradation. |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Protein Name | Polycomb Complex Protein Bmi-1Polycomb Group Ring Finger Protein 4Ring Finger Protein 51 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Polycomb Complex Protein Bmi-1 antibodyAnti-Polycomb Group Ring Finger Protein 4 antibodyAnti-Ring Finger Protein 51 antibodyAnti-BMI1 antibodyAnti-PCGF4 antibodyAnti-RNF51 antibody |
Information sourced from Uniprot.org
