| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Dog/Pig |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-BMI1 (237-251) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-5µg/mlELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: |
237-251 |
| Accession Number: |
NP_005171.4 |
| Immunogen Sequence: |
SHQRDGLTNAGELES |
| Post Translational Modifications | May be polyubiquitinated.which does not lead to proteasomal degradation. Monoubiquitinated. |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Protein Name | Polycomb Complex Protein Bmi-1Polycomb Group Ring Finger Protein 4 |
| Database Links | Reactome: R-MMU-3108214Reactome: -MMU-3899300Reactome: -MMU-4551638Reactome: -MMU-4570464Reactome: -MMU-8939243Reactome: -MMU-8943724Reactome: -MMU-8953750 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Polycomb Complex Protein Bmi-1 antibodyAnti-Polycomb Group Ring Finger Protein 4 antibodyAnti-Bmi1 antibodyAnti-Bmi-1 antibodyAnti-Pcgf4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
