| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BMI1 (120-326) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BMI1 |
| Gene ID: |
100532731/648 |
| Uniprot ID: |
BMI1_HUMAN |
| Immunogen Region: |
120-326 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-326 of human Bmi1 (NP_005171.4). |
| Immunogen Sequence: |
EDKRIITDDEIISLSIEFFD QNRLDRKVNKDKEKSKEEVN DKRYLRCPAAMTVMHLRKFL RSKMDIPNTFQIDVMYEEEP LKDYYTLMDIAYIYTWRRNG PLPLKYRVRPTCKRMKISHQ RDGLTNAGELESDSGSDKAN SPAGGIPSTSSCLPSPSTPV QSPHPQFPHISSTMNGTSNS PSGNHQSSFANRPRKSSVNG SSATSSG |
| Post Translational Modifications | Monoubiquitinated. May be polyubiquitinated.which does not lead to proteasomal degradation. |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Protein Name | Polycomb Complex Protein Bmi-1Polycomb Group Ring Finger Protein 4Ring Finger Protein 51 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Polycomb Complex Protein Bmi-1 antibodyAnti-Polycomb Group Ring Finger Protein 4 antibodyAnti-Ring Finger Protein 51 antibodyAnti-BMI1 antibodyAnti-PCGF4 antibodyAnti-RNF51 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
