| Host: | Rabbit |
| Applications: | IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BLOC1S3 |
| Gene ID: | 388552 |
| Uniprot ID: | BL1S3_HUMAN |
| Immunogen Region: | 1-202 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human BLOC1S3 (NP_997715.1). |
| Immunogen Sequence: | MASQGRRRRPLRRPETVVPG EATETDSERSASSSEEEELY LGPSGPTRGRPTGLRVAGEA AETDSEPEPEPEPTAAPRDL PPLVVQRESAEEAWGTEEAP APAPARSLLQLRLAESQARL DHDVAAAVSGVYRRAGRDVA ALASRLAAAQAAGLAAAHSV RLARGDLCALAERLDIVAGC RLLPDIRGVPGTEPEKDPGP RA |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. |
| Protein Name | Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 3Bloc-1 Subunit 3 |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 3 antibodyAnti-Bloc-1 Subunit 3 antibodyAnti-BLOC1S3 antibodyAnti-BLOS3 antibody |
Information sourced from Uniprot.org