Anti-BIK antibody (18-67) (STJ94348)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human BIK. AA range:18-67
General Information
| Short Description | Rabbit polyclonal anti-Bcl-2-interacting killer (18-67) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BIK |
| Gene ID | 638 |
| Uniprot ID | BIK_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BIK. AA range:18-67 |
| Immunogen Region | 18-67 |
| Specificity | NBK Polyclonal Antibody detects endogenous levels of NBK protein. |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism. Ubiquitinated by the ECS(ASB11) complex in response to endoplasmic reticulum stress, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. |
| Function | Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. |
| Protein Name | Bcl-2-Interacting KillerApoptosis Inducer NbkBip1Bp4 |
| Database Links | |
| Cellular Localisation | Endomembrane SystemSingle-Pass Membrane ProteinMitochondrion MembraneAround The Nuclear EnvelopeAnd In Cytoplasmic Membranes |
| Alternative Antibody Names | Anti-Bcl-2-Interacting Killer antibodyAnti-Apoptosis Inducer Nbk antibodyAnti-Bip1 antibodyAnti-Bp4 antibodyAnti-BIK antibodyAnti-NBK antibody |
Information sourced from Uniprot.org