| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BHMT |
| Gene ID: | 635 |
| Uniprot ID: | BHMT1_HUMAN |
| Immunogen Region: | 177-406 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 177-406 of human BHMT (NP_001704.2). |
| Immunogen Sequence: | SGKPVAATMCIGPEGDLHGV PPGECAVRLVKAGASIIGVN CHFDPTISLKTVKLMKEGLE AARLKAHLMSQPLAYHTPDC NKQGFIDLPEFPFGLEPRVA TRWDIQKYAREAYNLGVRYI GGCCGFEPYHIRAIAEELAP ERGFLPPASEKHGSWGSGLD MHTKPWVRARARKEYWENLR IASGRPYNPSMSKPDGWGVT KGTAELMQQKEATTEQQLKE LFEKQKFKSQ |
| Tissue Specificity | Found exclusively in liver and kidney. |
| Function | Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. |
| Protein Name | Betaine--Homocysteine S-Methyltransferase 1 |
| Database Links | Reactome: R-HSA-1614635Reactome: R-HSA-6798163 |
| Cellular Localisation | CytoplasmCytosolNucleusPredominantly Localized In The Cytoplasm With A Small Fraction Detected In The NucleusTranslocates Into The Nucleus Upon Oxidative Stress |
| Alternative Antibody Names | Anti-Betaine--Homocysteine S-Methyltransferase 1 antibodyAnti-BHMT antibody |
Information sourced from Uniprot.org