| Function | Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. |
| Protein Name | Protein Bex2Brain-Expressed X-Linked Protein 2Hbex2 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Protein Bex2 antibodyAnti-Brain-Expressed X-Linked Protein 2 antibodyAnti-Hbex2 antibodyAnti-BEX2 antibody |
Information sourced from Uniprot.org
