| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Bestrophin-2 is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: |
WB 1:500-1000IHC 1:200-500IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BEST2 |
| Gene ID: |
54831 |
| Uniprot ID: |
BEST2_HUMAN |
| Specificity: |
The antibody detects endogenous BEST2 protein. |
| Immunogen: |
Synthetic Peptide of BEST2 |
| Function | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide. Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture. Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion. In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate.binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans. Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate. |
| Protein Name | Bestrophin-2aVitelliform Macular Dystrophy 2-Like Protein 1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Bestrophin-2a antibodyAnti-Vitelliform Macular Dystrophy 2-Like Protein 1 antibodyAnti-BEST2 antibodyAnti-VMD2L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
