Anti-BEST2 antibody (388-404) {Biotin} (STJ500245)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 388-404 of mouse Bestrophin 2 protein, peptide was covalently modified.
General Information
| Short Description | Rabbit polyclonal antibody anti-BEST2 (388-404) is suitable for use in Confocal Microscopy, ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | CM/ELISA/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Monkey/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.75-1.2 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:200ICC: 1:200IF: 1:200CFM: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Best2 |
| Gene ID | 212989 |
| Uniprot ID | BEST2_MOUSE |
| Immunogen | Synthetic peptide taken within amino acid region 388-404 of mouse Bestrophin 2 protein, peptide was covalently modified. |
| Immunogen Region | 388-404 |
Additional Info
| Tissue Specificity | Expressed in mucin-secreting colonic goblet cells. |
| Function | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide. Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture. Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion. In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate.binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans. Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate. |
| Protein Name | Bestrophin-2Vitelliform Macular Dystrophy 2-Like Protein 1 |
| Database Links | Reactome: R-MMU-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Bestrophin-2 antibodyAnti-Vitelliform Macular Dystrophy 2-Like Protein 1 antibodyAnti-Best2 antibodyAnti-Vmd2l1 antibody |
Information sourced from Uniprot.org