| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BEST1 (376-585) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BEST1 |
| Gene ID: |
7439 |
| Uniprot ID: |
BEST1_HUMAN |
| Immunogen Region: |
376-585 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 376-585 of human BEST1 (NP_004174.1). |
| Immunogen Sequence: |
QPNQEDEEDAHAGIIGRFLG LQSHDHHPPRANSRTKLLWP KRESLLHEGLPKNHKAAKQN VRGQEDNKAWKLKAVDAFKS APLYQRPGYYSAPQTPLSPT PMFFPLEPSAPSKLHSVTGI DTKDKSLKTVSSGAKKSFEL LSESDGALMEHPEVSQVRRK TVEFNLTDMPEIPENHLKEP LEQSPTNIHTTLKDHMDPYW ALENRDEAHS |
| Tissue Specificity | Predominantly expressed in the basolateral membrane of the retinal pigment epithelium. |
| Post Translational Modifications | Phosphorylated by PP2A. |
| Function | Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. |
| Protein Name | Bestrophin-1Tu15bVitelliform Macular Dystrophy Protein 2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Bestrophin-1 antibodyAnti-Tu15b antibodyAnti-Vitelliform Macular Dystrophy Protein 2 antibodyAnti-BEST1 antibodyAnti-VMD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
