Anti-BDH2 antibody (STJA0007488)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human BDH2
General Information
| Short Description | Rabbit polyclonal anti-Dehydrogenase/reductase SDR family member 6-beta-hydroxybutyrate dehydrogenase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BDH2 |
| Gene ID | 56898 |
| Uniprot ID | DHRS6_HUMAN |
| Immunogen | Synthesized peptide derived from human BDH2 |
| Specificity | This antibody detects endogenous levels of BDH2 at Human, Mouse, Rat |
Additional Info
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 6(R-Beta-Hydroxybutyrate Dehydrogenase3-Hydroxybutyrate Dehydrogenase Type 24-Oxo-L-Proline ReductaseOxidoreductase UcpaShort Chain Dehydrogenase/Reductase Family 15c Member 1 |
| Database Links | Reactome: R-HSA-77111 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 6 antibodyAnti-(R-Beta-Hydroxybutyrate Dehydrogenase antibodyAnti-3-Hydroxybutyrate Dehydrogenase Type 2 antibodyAnti-4-Oxo-L-Proline Reductase antibodyAnti-Oxidoreductase Ucpa antibodyAnti-Short Chain Dehydrogenase/Reductase Family 15c Member 1 antibodyAnti-BDH2 antibodyAnti-DHRS6 antibodyAnti-SDR15C1 antibodyAnti-UNQ6308 antibodyAnti-PRO20933 antibody |
Information sourced from Uniprot.org