| Host: |
Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
BCL2L10 |
| Gene ID: |
10017 |
| Uniprot ID: |
B2L10_HUMAN |
| Immunogen Region: |
11-140 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 11-140 of human BCL2L10 (NP_065129.1). |
| Immunogen Sequence: |
MADPLRERTELLLADYLGYC AREPGTPEPAPSTPEAAVLR SAAARLRQIHRSFFSAYLGY PGNRFELVALMADSVLSDSP GPTWGRVVTLVTFAGTLLER GPLVTARWKKWGFQPRLKEQ EGDVARDCQR |
| Tissue Specificity | Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. |
| Post Translational Modifications | Monoubiquitinated by UBQLN1.results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm. |
| Function | Promotes cell survival by suppressing apoptosis induced by BAX but not BAK. Increases binding of AHCYL1/IRBIT to ITPR1. Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions. Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis. Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2. |
| Protein Name | Bcl-2-Like Protein 10Bcl2-L-10Anti-Apoptotic Protein BooAnti-Apoptotic Protein NrhApoptosis Regulator Bcl-B |
| Cellular Localisation | MitochondrionNucleus MembraneEndoplasmic ReticulumCytoplasmCytoskeletonSpindleLocalizes To Mitochondria-Associated Endoplasmic Reticulum Membranes (Mams)Localization To Mams Is Greatly Reduced Under Apoptotic Stress Conditions |
| Alternative Antibody Names | Anti-Bcl-2-Like Protein 10 antibodyAnti-Bcl2-L-10 antibodyAnti-Anti-Apoptotic Protein Boo antibodyAnti-Anti-Apoptotic Protein Nrh antibodyAnti-Apoptosis Regulator Bcl-B antibodyAnti-BCL2L10 antibodyAnti-BCL-B antibodyAnti-BCLB antibodyAnti-BOO antibodyAnti-DIVA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
