Anti-bcl-2 antibody [E17] (STJ16100312)

SKU:

STJ16100312

£1,247.50

General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	IHC-P
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-bcl-2 is suitable for use in Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	E17
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Dilution Range:	IHC 1:25-1:100
Storage Instruction:	Store at 2-8°C upon receipt.

Background

BCL2 is a protein associated with apoptosis regulation produced by the bcl-2 gene, located on chromosome 14q32.BCL2 is comprised of an alpha (239 amino acids) and beta chain. BCL2 (and thus BCL2 alpha chain) is found in mitochondrial and nuclear membranes and in the cytosol rather than the cell surface. In normal lymphoid tissue, BCL2 antibody reacts with small B-lymphocytes in the mantle zone and many cells within the T-cell areas. Anti-BCL2 has shown consistent negative reaction on reactive germinal center B-cells and positive staining of neoplastic follicles in follicular lymphoma. This antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. This antibody may also be used in distinguishing between those follicular lymphomas that express BCL2 protein and the small number in which the neoplastic cells are BCL2 negative.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

reviews