Anti-BBS2 antibody (1-96) (STJ29561)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BBS2 (1-96) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BBS2 |
| Gene ID | 583 |
| Uniprot ID | BBS2_HUMAN |
| Immunogen Region | 1-96 |
| Immunogen Sequence | MLLPVFTLKLRHKISPRMVA IGRYDGTHPCLAAATQTGKV FIHNPHTRNQHVSASRVFQS PLESDVSLLNINQAVSCLTA GVLNPELGYDALLVGT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-96 of human BBS2 (NP_114091.3). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. |
| Protein Name | Bbsome Complex Member Bbs2Bardet-Biedl Syndrome 2 Protein |
| Database Links | Reactome: R-HSA-5620922 |
| Cellular Localisation | Cell ProjectionCilium MembraneCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar Satellite |
| Alternative Antibody Names | Anti-Bbsome Complex Member Bbs2 antibodyAnti-Bardet-Biedl Syndrome 2 Protein antibodyAnti-BBS2 antibody |
Information sourced from Uniprot.org