| Host: |
Rabbit |
| Applications: |
WB/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Bcl-2-binding component 3, isoforms 1/2 (120-169 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IF 1:100-300ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BBC3 |
| Gene ID: |
27113 |
| Uniprot ID: |
BBC3_HUMAN |
| Immunogen Region: |
120-169 aa |
| Specificity: |
PUMA Polyclonal Antibody detects endogenous levels of PUMA protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human PUMA at the amino acid range 120-169 |
| Function | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis. Regulates ER stress-induced neuronal apoptosis. |
| Protein Name | Bcl-2-Binding Component 3 - Isoforms 1/2Jfy-1P53 Up-Regulated Modulator Of Apoptosis |
| Database Links | Reactome: R-HSA-111453Reactome: R-HSA-139915Reactome: R-HSA-6803204Reactome: R-HSA-9614657 |
| Cellular Localisation | MitochondrionLocalized To The Mitochondria In Order To Induce Cytochrome C Release |
| Alternative Antibody Names | Anti-Bcl-2-Binding Component 3 - Isoforms 1/2 antibodyAnti-Jfy-1 antibodyAnti-P53 Up-Regulated Modulator Of Apoptosis antibodyAnti-BBC3 antibodyAnti-PUMA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
