| Post Translational Modifications | Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription. Phosphorylated. |
| Function | AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGACGTCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs. |
| Protein Name | Basic Leucine Zipper Transcriptional Factor Atf-LikeB-Cell-Activating Transcription FactorB-AtfSf-Ht-Activated Gene 2 ProteinSfa-2 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | NucleusCytoplasmPresent In The Nucleus And CytoplasmBut Shows Increased Nuclear Translocation After Activation Of T-Cells |
| Alternative Antibody Names | Anti-Basic Leucine Zipper Transcriptional Factor Atf-Like antibodyAnti-B-Cell-Activating Transcription Factor antibodyAnti-B-Atf antibodyAnti-Sf-Ht-Activated Gene 2 Protein antibodyAnti-Sfa-2 antibodyAnti-BATF antibody |
Information sourced from Uniprot.org
