Anti-BAP31 antibody [R03-6R3] (STJA0036917)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human BAP31
General Information
| Short Description | Rabbit monoclonal anti-BAP31 for use in WB, IHC-P, ICC, IF and FC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-6R3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | BCAP31 |
| Gene ID | 10134 |
| Uniprot ID | BAP31_HUMAN |
| Immunogen | A synthesized peptide derived from human BAP31 |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in neurons and discrete endocrine cells. |
| Post Translational Modifications | Cleaved by CASP8 and other caspases. |
| Function | Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40. In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2. May be involved in CASP8-mediated apoptosis. |
| Protein Name | B-Cell Receptor-Associated Protein 31Bcr-Associated Protein 31Bap316c6-Ag Tumor-Associated AntigenProtein CdmP28 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-75153Reactome: R-HSA-8980692Reactome: R-HSA-983170Reactome: R-HSA-9833110 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneMay Shuttle Between The Er And The Intermediate Compartment/Cis-Golgi ComplexAssociates With The Mitochondria-Associated Endoplasmic Reticulum Membrane Via Interaction With Tomm40(Microbial Infection) Upon Sv40 InfectionColocalizes With Dnajc18Dnajb12 And Dnajb14 In Punctate Structures Within The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-B-Cell Receptor-Associated Protein 31 antibodyAnti-Bcr-Associated Protein 31 antibodyAnti-Bap31 antibodyAnti-6c6-Ag Tumor-Associated Antigen antibodyAnti-Protein Cdm antibodyAnti-P28 antibodyAnti-BCAP31 antibodyAnti-BAP31 antibodyAnti-DXS1357E antibody |
Information sourced from Uniprot.org