| Short Description : | Rabbit polyclonal anti-BACH2 (360-410 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | BACH2 |
| Gene ID: | 60468 |
| Uniprot ID: | BACH2_HUMAN |
| Immunogen: | A synthetic peptide from aa region 360-410 of human BACH2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region: | 360-410 aa |
| Specificity: | Specific for BACH2. |
| Post Translational Modifications | Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export. The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses. |
| Function | Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation. |
| Protein Name | Transcription Regulator Protein Bach2Btb And Cnc Homolog 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleocytoplasmic Shuttling Is Controlled By Phosphorylation |
| Alternative Antibody Names | Anti-Transcription Regulator Protein Bach2 antibodyAnti-Btb And Cnc Homolog 2 antibodyAnti-BACH2 antibody |
Information sourced from Uniprot.org
